The desire to be bigger and stronger is an objective a large subset of the bodybuilding
community possess. To realize that goal by natural means has eluded those who covet the
extreme size. Sure, there are several respectable natural anabolic supplements currently
available such as Olympus Labs -epicatechin product, EP1C UNLEASHED. But lets be REAL,
they’re not in the same realm as a PH. That unfortunate reality makes the
temptation to use a PH too appealing for many to resist. For those that are not willing to accept
the risks that several PH products present, they be may destined to remain ”small”?
Unless the DemiGods at Olympus Labs can solve this conundrum and help you get HUGE!.
We went back to the fundamentals to create the ultimate catalyst for natural growth. Olympus
Labs is proud to announce a TR1UMPH in the natural anabolic category with the inception of
OR1GIN – The King of Natural Anabolics. It is the missing link in your quest to transform from a
mere mortal into a DemiGod.
It is a revolutionary supplement that will not have an impact on the Hypothalamic Pituitary
Testicular Axis (HPTA), glands in the human body that affect the production of testosterone.
Yet it is so advanced it will stimulate muscle growth never realized before from a natural product
and will undoubtedly change your approach to supplementation. Olympus Labs has created the
OR1GIN of muscle building to re-define your physique – naturally. There is now a viable
alternative for those who want to boost muscle anabolism without the use of prohormones.
OR1GIN is also a perfect addition to a pro-hormone cycle or to use as part of a post-cycle
therapy (PCT) to maintain your gains.
So how does OR1GIN work exactly? Well, I am sure you are familiar with the popular cliche in
the bodybuilding community; “you need to eat to grow”. That is a very simplistic perspective
and often misinterpreted by those who follow bro-science. Although it may be easy to
significantly increase caloric intake with foods high in fat and sugar, It is not as easy to do so
while adhering to a healthy diet. To avoid eating when you are not hungry otherwise known as
“force feeding“, an increase in appetite would be ideal. In addition, you want to ensure your
body utilizes those extra calories in the most efficient manner, mainly in the form of skeletal
muscle. Guess what? OR1GIN adeptly performs those two functions via ghrelin secretion and
ribosome biogenesis. In order to understand the potential of OR1GIN, let’s review these two
mechanism of actions.
Enhanced Ribosome Biogenesis
Increased Ghrelin Release & Myogenin Synthesis
Increased IGF-1 Signaling
Accelerated Recovery & Tissue Healing
Increased Appetite & Improved Digestion/Nutrient Uptake
Ghrelin is an endogenous ligand, GHS-R1a, of the growth hormone secretagogue receptor that
can cause a significant increase in appetite. In fact, Ghrelin is the only hormone that exhibits
this appetite enhancement, or orexigenic effect, following peripheral administration. In addition,
ghrelin exhibits a variety of actions, including stimulation of growth hormone secretion, gastric
motility, and gastric acid secretion, as well as induction of a positive energy balance. This
hormone, predominantly expressed and secreted by the stomach, has a dual action on GH
secretion and food intake. It is believed to be the link connecting somatic growth and body
composition with energy metabolism.
The ribosome is a nucleoprotein particle responsible for one of the key processes in every cell,
the decoding of messenger ribonucleic acid (mRNA) into protein. mRNA is a set of RNA
molecules that translate genetic information from DNA to the ribosome. Formation of the
ribosomal particle, also referred to as ribosome biogenesis, involves a complex series of
processes (synthesis, processing and modification) of both ribosome ribonucleic acid (rRNA)
and ribosomal proteins, and assembly of the components. Ribosomes play a pivotal role in the
molecular life of every cell and rRNA is a critical component of protein synthesis. The
biogenesis of ribosomes is a tightly regulated activity and it is inextricably linked to other
fundamental cellular processes, including growth, or muscle hypertrophy, and cell division as
the studies below demonstrate.
Forty-two older adults underwent a 4 week resistance exercise training (RT)
program to validate the hypothesis that the extent of hypertrophy is at
least partly regulated by the amount of RT-induced ribosome biogenesis.
The study aimed to induce hypertrophy with knee extensors (e.g. 2 sets of
squat, leg press, and knee extension, 10-12RM, 3d/wk), and vastus lateralis
muscle biopsies were performed pre- and post-RT. Post hoc K-means cluster
analysis revealed distinct differences in Type II myofiber hypertrophy
among subjects. The percent change in Type II myofiber size in non-
responders (Non; n=17) was -7%, moderate responders (Mod; n=19) +22%, and
extreme responders (Xtr; n=6) +83%. Total muscle RNA increased only in Mod
(+9%, p<0.08) and Xtr (+26%, p<0.01), and only Xtr increased rRNA content
(+40%, p<0.05) and myonuclei/type II fiber (+32%, p<0.01). Additionally,
Mod and Xtr had a greater increase in c-Myc protein levels when compared to
Non (e.g. ≈+350% and ≈+250% vs. +≈50%, respectively; p<0.05). In vitro
studies showed that growth factor-induced human myotube hypertrophy is
abolished when rRNA synthesis is knocked down using the Pol I-specific
inhibitor, CX-5461. Overall, these data indicate ribosome biogenesis as a
key process regulating the extent of RT-induced myofiber hypertrophy in
An animal study was performed to analyze the impact of increases in the protein translation rate
from external loads on muscle hypertrophy. Male rats were assigned to four groups in which the
plantaris muscle was unilaterally subjected to weak (WK), moderate (MO), middle (MI), and
strong (ST) overloading by four types of synergist ablation. Fourteen days after surgery, the
weight of the plantaris muscle per body weight increased by 8%, 22%, 32% and 45%, in the
WK, MO, MI and ST groups, respectively. Five days after surgery, 18+28S rRNA content (an
indicator of translational capacity) increased with increasing overload, with increases of 1.8-fold
(MO), 2.2-fold (MI), and 2.5-fold (ST), respectively, relative to non-overloaded muscle (NL) in
the WK group. rRNA content showed a strong correlation with relative muscle weight measured
14 days after surgery (r = 0.98). The phosphorylated form of p70S6K (a positive regulator of
translational efficiency) showed a marked increase in the MO group, but no further increase was
observed with further increase in overload (increases of 22.6-fold (MO), 17.4-fold (MI), and
18.2-fold (ST), respectively, relative to NL in the WK group). These findings indicate that
increases in ribosome biogenesis at the early phase of overloading are strongly dependent on
the amount of overloading, and may play an important role in increasing the translational
capacity for further gain of muscular size.
A clinical study with mice sought to examine the hypothesis that a change in the expression of
protein-encoding genes in response to a hypertrophic stimulus contributes to the blunted
hypertrophy observed with aging. To test this theory, gene expression of plantaris muscle from
5 month and 25 month old mice were subjected to synergist ablation to induce hypertrophy over
the course of two weeks. A similar pattern of expression between the two groups was found.
Despite ribosome protein gene expression being higher in the aged group, ribosome biogenesis
was significantly blunted in the skeletal muscle of aged mice compared with mice young in
response to the hypertrophic stimulus (50% vs. 2.5-fold, respectively). The failure to upregulate
pre-47S ribosomal RNA (rRNA) expression in muscle undergoing hypertrophy of old mice
indicated that rDNA transcription by RNA polymerase I was impaired. These results indicate
that the hypothesis was incorrect, impaired ribosome biogenesis was a primary factor
underlying the blunted hypertrophic response observed in skeletal muscle of old mice rather
than dramatic differences in the expression of protein-encoding genes. Therefore improved
ribosome biogenesis may result in an increased hypertrophic response observed in older
So what is in OR1GIN that will increase ghrelin secretion and ribosome biogenesis? It utilizes
four effective ingredients supported by clinical data in one potent matrix to induce significant
muscle anabolism. The GHrow matrix is comprised of 750mg of Hesperidin Methyl Chalcone,
600mg of Gentian Root extract, 300mg of Robuvit® (Quercus Robur) extract and 300mg of
Actractylodes Chinesis that work in tandem to help you grow! These are likely not compounds
you would typically associate with a bodybuilding supplement and that is because OR1GIN is
atypical. There is no other natural product that is in the same realm as OR1GIN. It is an
exceptional formula that will provide exceptional results. As always, Olympus Labs builds our
formulations on thorough research and sound science which is reflected in the complete dosing
of each ingredient.. In fact, OR1GIN contains a very high dose of Robuvit® and Actractylodes
compared to dosages seen in the studies. So you can rest assured OR1GIN will maximize
muscle anabolism in order to build your ultimate physique.
Hesperidin is a flavanone glycoside or a sugar molecule consisting of the flavone hesperitin
bound to the disaccharide rutinose. It is naturally occurring in citrus fruits including oranges,
tangerines and grapefruits. Hesperidin has been shown to influence several biological functions,
including inhibiting tumor development and the proliferation of human cancer cells, as well as
the destruction of cancer cells. It also has antibacterial, antiviral, and antifungal properties. In
vivo studies have shown that hesperidin may also play a role in ghrelin secretion from the
stomach through antagonism of the serotonin receptors.
A study with mouse muscle cells was performed to assess the in vivo and in vitro effect of
hesperidin on myogenic differentiation (muscle tissue formation). The cells were analyzed in
the presence and absence of hesperidin for the in vitro portion of the study using several lab
testing methods, including reporter gene assays, immunoblotting, RT-PCR and DNA pull-down
assays. In vivo, the effects of hesperidin were assessed using the freeze injury-induced
muscle regeneration model in mice and daily injections of hesperidin for 6 days. Hesperidin
promoted myogenic differentiation, in a dose-dependent manner, by increasing myogenin gene
expression. Myogenin is a gene transcriptor in mice that plays a critical role in the development
of functional skeletal muscle. Hesperidin increased myogenin and muscle creatine kinase gene
expression during myogenic differentiation from C3H10T1/2 mesenchymal stem cells in a
MyoD-dependent manner and accelerated in vivo muscle regeneration induced by muscle
injury. These results indicate hesperedin can play a beneficial role in promoting muscle
regeneration, following injury.
Gentian root is a a herbal bitter that is derived from the perennial, Gentiana lutea L. It has
traditionally been used in the treatment of digestive disorders and is an ingredient of many
proprietary medicines. It contains secoiridoid glucosides which are some of the most bitter
compounds known and is used as a scientific basis for measuring bitterness. Gentiana lutea is
known to have several biological effects, such as anti-oxidant, anti-tumor and hepatoprotective
properties. Recent clinical research into Gentian root and other bitter compounds found that
observed improvements in digestion and appetite may at least be partly ascribed to the bitter
tonic effect. The increase in appetite that Gentian root provides can be attributed to its ability to
stimulate ghrelin secretion. If you want grow you will need to get those macros in and the
significant improvement in digestion that Gentiana lutea provides will make larger meals more
tolerable. At the substantial dosage included in OR1GIN it will be extremely effective in that
Robuvit® is a patented natural extract from French oak wood (Quercus robur) that is rich in
roburins and other flavonoids. It is typically used to improve liver dysfunction and chronic
fatigue. However, more pertinent to bodybuilding is its ability to reduce muscle soreness,
accelerate recovery and to induce changes in the function of the cellular protein factories called
ribosomes. Defective ribosomal function has been shown to be associated with several
diseases such as chronic fatigue syndrome (CFS). In addition, Robuvit® has passed extensive
safety tests and GLP (Good Laboratory Practice) studies,and is considered safe for human
consumption based on the fact no toxic effects have been observed or reported in clinical trials.
A clinical study confirmed human absorption of roburins from a French oak wood (Quercus
robur) water extract (Robuvit) by measuring the increase of total phenols (from 0.63 ± 0.06 to
1.26 ± 0.18 μg GAE equiv/mL plasma) and the appearance of three different roburin metabolites
(glucoronidate, urolithins and ellagic acid), in plasma, after 5 days of supplementation. Robuvit
supplementation also induced the increase of plasma antioxidant capacity from 1.8 ± 0.05 to 1.9
± 0.01 nmol Trolox equiv/mL plasma. The study concluded that Robuvit metabolites affect
ribosome, cell cycle, and spliceosome pathways.
A clinical study was performed to evaluate the effects of supplementation with Robuvit®
(Quercus robur wood extract, or "QR") on performance and endurance in amateur athletes
training for a triathlon for a period of 2 weeks. All subjects, half which supplemented with
Robuvit® and 27 did not, completed 3 events; (swimming, biking and running). Each group
improved in training in each of the 3 events, however the improvement was greater with
Robuvit® (P<0.05) for the swim and biking (P<0.05); the running time decreased by 12.32% in
subjects using Robuvit® (3.6% in controls; P<0.05). The improvement the total triathlon time
was -10.56% with Robuvit® in comparison to -3.41% in controls. Post-run muscular pain,
cramps, localized pain, straining and the recovery time, were all considered better with QR
(P<0.05) based on plasma free radical (PFR) values 1 hour after the final run. After the final
test run triathlon athletes using QR had a lower increase of UBR and LDH (indicator of
hemolysis). These two tests were significantly increased in controls (P<0.05) but not in the
Robuvit® group. The observed improvements in triathlon athletes who supplemented are
significant since this group of athletes is among the best trained in the world, therefore it is
difficult to improve even further without severe training. In conclusion, Robuvit®
supplementation improved training, results and decreased hemolysis or the elimination of red
blood cells.. In addition, no side effects or tolerance problems were reported. .
Another clinical study investigated the effect of supplementation with Robuvit® (French Quercus
robur extract) capsules in subjects with Chronic Fatigue Syndrome (CFS) associated with
increased oxidative stress. The supplementation group consisted of 38 CFS subjects who
received 300 mg/day of Robuvit® and a control group of 42 comparable subjects who were
evaluated for 6 months following an initial 4 week washout period. Symptoms improved in both
groups with a significantly more important improvement in the supplement group (P<;0.05). The
single items in the Multidimensional Assessment of Fatigue (MAF) questionnaire were
statistically better improved (P<;0.05) in the supplement group. A parallel improvement in
oxidative stress was observed in the supplemented subjects. In the follow up, at 6 months no
organic disease was discovered or disease markers found. The study concluded that
supplementation with Robuvit® improves CFS in otherwise healthy subjects with no presence of
clinical disease or risk conditions.
Atractylodin is a derivative of the Atractylodes herb, a member of the Asteraceae family. There
are three different species: Atractylis lancea (Thunb.). DC., Atractylodes japonica Koidz.ez
Kitam and Atractylodes chinesis (DC.) koidz. It has been traditionally used as treatment for
several conditions including diarrhea, atrophy and flaccidity, arthralgia (joint pain) due to wind
and dampness and loss of appetite. Similar to Gentian root, the effect on appetite that
Atractylodin causes is indicative of ghrelin secretion. As detailed in the study below,
Atractylodin has been shown to be effective with hesperidin induces ghrelin receptor signaling.
Active components of rikkunshito, hesperidin and atractylodin, were given to tumor-bearing rats
to determine their efficacy as a treatment for cancer anorexia–cachexiaé It is a syndrome that
results in decreased food intake, weight loss, muscle tissue wasting and psychological distress,
and this syndrome is a major source of increased morbidity and mortality in cancer patients.
Corticotropin-releasing factor (CRF) decreased the plasma level of acyl ghrelin, and its receptor
antagonist, α-helical CRF, increased food intake of these rats. The serotonin 2c receptor (5-
HT2cR) antagonist SB242084 decreased hypothalamic CRF level and improved anorexia,
gastrointestinal (GI) dysmotility and body weight loss. The ghrelin receptor antagonist (D-Lys3)-
GHRP-6 worsened anorexia and hastened death in tumor-bearing rats. Ghrelin attenuated
anorexia–cachexia in the short term, but failed to prolong survival, as did SB242084
administration. In addition, the herbal medicine rikkunshito improved anorexia, GI dysmotility,
muscle wasting, and anxiety-related behavior and prolonged survival in animals and patients
with cancer. The appetite-stimulating effect of rikkunshito was blocked by (D-Lys3)- GHRP-6
Active components of rikkunshito, hesperidin and atractylodin potentiated ghrelin secretion and
receptor signaling, respectively, and atractylodin prolonged survival in tumor-bearing rats. Our
study demonstrates that the integrated mechanism underlying cancer anorexia–cachexia
involves lowered ghrelin signaling due to excessive hypothalamic interactions of 5-HT with CRF
through the 5-HT2cR. Potentiation of ghrelin receptor signaling may be an attractive treatment
for anorexia, muscle wasting and prolong survival in patients with cancer anorexia–cachexia.
Olympus Labs went to the OR1GIN to create fundamental anabolic staple for DemiGods. The
quest for the ultimate natural anabolic to facilitate your transformation from a mere mortal into a
DemiGod is complete. The King of Natural Anabolics has been crowned with inception of
With the reputation Olympus Labs has established for Innovation, Value and Results, you can
have complete confidence that OR1GIN will deliver a significant boost in muscle anabolism. By
stimulating ghrelin secretion and ribosome biogenesis, OR1GIN will increase appetite, energy
metabolism and muscle hypertrophy. There are no other natural supplements available that
can rival the anabolic potential of OR1GIN.
Whether you want to pack on muscle without the use of prohormones, to optimize a PH cycle or
maintain gains in PCT, OR1GIN has you covered. You had to ENDUR3 long enough without a
natural product with the impressive potential of OR1GIN. The wait is now over and It is time to
IGNIT3 your anabolic furnace and TR1IUMPH over mediocrity. You must begin at the OR1GIN
to build the ultimate, natural, physique and join the ranks of the DemiGods!
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Eukaryotic ribosome biogenesis at a glance.
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10.1152/ajpendo.00486.2015. [Epub ahead of print]. Ribosome biogenesis may
augment resistance training-induced myofiber hypertrophy and is required for myotube
growth in vitro.
5. Nakada S et al. PLoS One. 2016 Jan 29;11(1):e0147284. doi:
10.1371/journal.pone.0147284. eCollection 2016. Correlation between Ribosome
Biogenesis and the Magnitude of Hypertrophy in Overloaded Skeletal Muscle.
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10.1152/japplphysiol.00296.2015. Epub 2015 Jun 5. Blunted hypertrophic response in
aged skeletal muscle is associated with decreased ribosome biogenesis.
7. Suzuki H et al. Recent Pat Food Nutr Agric. 2014;6(1):60-3. Hesperidin potentiates
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5381.2011.01243.x. Hesperedin promotes MyoD-induced myogenic differentiation in
vitro and in vivo.
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10.1016/j.jep.2013.03.059. Epub 2013 Mar 30. Bitterness values for traditional tonic
plants of southern Africa.
11. Kusar A et al. Human & Experimental Toxicology (2006) 25: 599-604. Free radical
scavenging activities of yellow gentian (Gentiana lutea L.) measured by electron spin
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10.1016/j.jep.2014.04.041. Epub 2014 May 5. Bitter tastants alter gastric-phase
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Epub 2014 Jan 6. Absorption, metabolism, and effects at transcriptome level of a
standardized French oak wood extract, Robuvit, in healthy volunteers: pilot study
15. Vinciguerra MG et al. Minerva Cardioangiol. 2015 Oct;63(5):403-9. Robuvit® and
endurance in triathlon: improvements in training performance, recovery and oxidative
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(Quercus robur extract) supplementation in subjects with chronic fatigue syndrome and
increased oxidative stress. A pilot registry study.
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doi: 10.1038/tp.2011.25. Potentiation of ghrelin signaling attenuates cancer
anorexia–cachexia and prolongs survival
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